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Cat No. : KO803462
Gene Name: LRP6
Gene No.: 4040
NM.: NM_002336.2
KO Cell Line: HEK293
Genome Location: Chromosome 12 12266710(deletion) 12266713-12266736(deletion) 12266711-12266712(mutation)
Specification: 10E6cell/tube,2 tubes
Price: $4995
Turnaround Time: 2weeks
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined
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